Mary E. Klotman, MD
Mary E. Klotman, MD, is chair of the Department of Medicine for Duke University School of Medicine.
An accomplished scientist and clinician, Klotman held the position of chief of the Division of Infectious Diseases at Mount Sinai for 13 years prior to becoming Duke Department of Medicine chair in 2010.
In 2007 she was named co-director of Mount Sinai’s Global Health and Emerging Pathogens Institute, a program designed to translate basic science discoveries into clinical therapeutics for newly emerging and re-emerging infectious diseases. Prior to that appointment, she had served as director of the Emerging Pathogens Center. She was also a professor of medicine and microbiology and associate professor of gene and cell medicine at Mount Sinai.
Klotman earned her undergraduate (zoology) and medical degrees from Duke, having completed her residency, as well as a fellowship in infectious diseases, in the Department of Medicine at Duke.
She also served as assistant professor of medicine at Duke before moving to the National Institutes of Health where she was a member of the Public Health Service and worked in the Laboratory of Tumor Cell Biology under the direction of Dr. Robert C. Gallo.
Klotman’s research interests are focused on the molecular pathogenesis of human immunodeficiency virus 1 (HIV-1) infection. Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease.
Her research group has also determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, and most recently in developing topical microbicides that could be used to block sexual transmission. She has mentored a number of pre- and post-doctoral students in laboratory-based research in infectious diseases.
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