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Brigid Hogan, PhD

Brigid Hogan, PhD

Brigid Hogan, PhD, chair of the Department of Cell Biology at Duke University Medical Center since the fall of 2002, is the first woman to chair a basic science department at DUMC. She is well respected throughout the world for her advances in developmental biology and stem cell research.

The British scientist grew up in a small village 30 miles northwest of London. She studied biochemistry at Cambridge University and did postdoctoral work at the Massachusetts Institute of Technology. Before moving to Vanderbilt University Medical Center in Nashville in 1988, she was head of the Laboratory of Molecular Embryology at the National Institute for Medical Research in London. She also taught each summer at the Cold Spring Harbor Laboratory, a leading research and teaching center on Long Island, New York.

She came to Duke from Vanderbilt, where she was a Howard Hughes Medical Institute (HHMI) investigator and director of the stem cell and organogenesis program. A developmental biologist, Hogan's research is designed to lead to a better understanding of the genetic origins of birth defects, and the repair and regeneration of damaged adult tissues. Her laboratory uses the mouse as a model system to explore the molecular, cellular and genetic basis for organogenesis, the process by which complex organs develop from small rudiments of undifferentiated stem cells. Over the last few years her work has focused on the development and repair of the lung and other endodermal organs.

In 1994 Hogan was the scientific co-chair of a National Institutes of Health report on human embryo research. Her work with primordial germ cells from the early mouse embryo led to the discovery of new ways of generating pluripotent stem cells. Pluripotent stem cells have the widest application because they can develop into almost all known types of cell.

She a member of the National Academy of Sciences and the Institute of Medicine, a fellow of the American Academy of Arts and Sciences and a fellow of the Royal Society of London, among other prestigious groups.



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